This is pure speculation, but in looking at this long seal from Mohenjo-daro [M-1271], and seal signs from Mesopotamia which we know the meaning of, it could just be that some of the Indus signs are also names of places or of particular cities.
Answer to question 52. from our panel of leading ancient Indus archaeologists.
The research carried out in Sindh during the last forty years, and the study of the chipped stone assemblages stored in Karachi University collections, show that Late (Upper) Palaeolithic [50,000-10,000 years ago] complexes are known from at least five regions of Sindh. Most sites are located close to good quality raw material outcrops and freshwater sources.
Bridget Allchin, a pioneering woman archaeologist of South Asia, recently passed away. The Guardian has a fine summary of her remarkable career.
In 1933, Ernest Mackay wrote about his meeting with a craftsman named Sahebdino in Sehwan (Sindh) who showed him how to etch carnelian.
Another sign of the growing importance of archaeobotanical datasets and the way in which qualitative and quantitative analysis can be used to paint a richer picture of something as complex as agriculture and nutrition in ancient Indus times.
A beautiful music video taking you to the ancient and modern town and surroundings of Harappa, from the magnificent banyan tree in the museum garden, to the galleries, bones and pottery.
"Following these criteria, at least one Harappan toponym can be isolated with a fair amount of confidence. Altogether 70 Indus insciptions have been recovered from Chanhujo-daro. Eleven of them contain the sign [shown], which is not known from any of the other thousands of Indus inscriptions found at other sites," writes Asko Parpola.
Recently published research describes how engravings on Harappan stamp seals allow the identification of particular artisans in the past. He explains how 3D optical microscopy can be used on these engravings to reconstruct how past production events were undertaken by different individual carvers.